Pubblicazione scientifica

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S.canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

DATA

Data di pubblicazione: 27/08/2016

AUTORI

CROAKER ANDREW
KING GRAHAM J
PYNE JOHN H
ANOOPKUMAR-DUKIE SHAILENDRA
LIU LEI

ENTE DI AFFERENZA

SOUTHERN CROSS PLANT SCIENCE SOUTHERN CROSS UNIV LISMORE NSW 2480 AUSTRALIA GRAHAM KING SCU EDU AU
SCHOOL OF MEDICINE UNIV QUEENSLAND ST LUCIA QLD 4072 AUSTRALIA J PYNE UQ EDU AU
SCHOOL OF PHARMACY GRIFFITH UNIV GOLD COAST CAMPUS GOLD COAST QLD 4222 AUSTRALIA S DUKIE GRIFFITH EDU AU

RIVISTA

International Journal of Molecular Sciences, 17(9), 1414

IMPACT FACTOR

4,210

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