Pubblicazione scientifica

Homogeneous Biosensing Based on Magnetic Particle Labels

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation.

DATA

Data di pubblicazione: 06/06/2016

AUTORI

SCHRITTWIESER STEFAN
PELAZ BEATRIZ
PARAK WOLFGANG J
LENTIJO-MOZO SERGIO
SOULANTICA KATERINA
DIECKHOFF JAN
LUDWIG FRANK
GUENTHER ANNEGRET
TSCHOPE ANDREAS
SCHOTTER JOERG

ENTE DI AFFERENZA

MOLECULAR DIAGNOSTICS AIT AUSTRIAN INST TECH VIENNA1220 AUSTRIA JOERG SCHOTTER AIT AC AT
FACHBEREICH PHYSIK PHILIPPS UNIV
LAB DE PHYSIQUE & CHIM DES NANO OBJETS LPCNO UNIV TOULOUSE INSA UPS CNRS TOULOUSE 31077 FRANCE SERGIOLENTIJO GMAIL COM SL M KSOULANT INSA TOULOUSE FR KS
INST ELEC MEASUREMENT & FUNDAMENTAL ELEC ENG TU BRAUNSCHWEIG BRAUNSCHWEIG
EXPERIMENTALPHYSIK UNIV SAARLANDES SAARBRUCKEN 66123 GERMANY ANNEGRET GUENTHER WEB DE AG A TSCHOEPE NANO UNI SAARLAND DE AT

RIVISTA

Sensors (Basel, Switzerland), 16(6), 828

IMPACT FACTOR

3,510

indietro