Pubblicazione scientifica

Brain serotonergic activation in growth-stunted farmed salmon: adaption versus pathology

FILONE TECNOLOGICO	TEMA
produzione e raccolta
trasformazione e commercializzazione

RIASSUNTO

Signalling systems activated under stress are highly conserved, suggesting adaptive effects of their function. Pathologies arising from continued activation of such systems may represent a mismatch between evolutionary programming and current environments. Here, we use Atlantic salmon (Salmo salar) in aquaculture as a model to explore this stance of evolutionary-based medicine, for which empirical evidence has been lacking. Growth-stunted (GS) farmed fish were characterized by elevated brain serotonergic activation, increased cortisol production and behavioural inhibition. We make the novel observation that the serotonergic system in GS fish is unresponsive to additional stressors, yet a cortisol response is maintained. The inability of the serotonergic system to respond to additional stress, while a cortisol response is present, probably leads to both imbalance in energy metabolism and attenuated neural plasticity. Hence, we propose that serotonin-mediated behavioural inhibition may have evolved in vertebrates to minimize stress exposure in vulnerable individuals.

DATA

Data di pubblicazione: 25/05/2016

AUTORI

VINDAS MARCO A
JOHANSEN IDA B
FOLKEDAL OLE
HOGLUND ERIK
GORISSEN MARNIX
FLIK GERT
KRISTIANSEN TORE S
ØVERLI ØYVIND

ENTE DI AFFERENZA

DEPT BIOSCIENCES UNIV OSLO
UNI RSCH AS
BJ RKNES COLLEGE OSLO NORWAY
INST MARINE RSCH 5984 MATREDAL NORWAY
NATL INST AQUATIC RESOURCES SECTION FOR AQUACULTURE TECH UNIV DENMARK NORTH SEA CTR
DEPT ORGANISMAL ANIMAL PHYSIOLOGY RADBOUD UNIV INST WATER & WETLAND RSCH
DEPT ANIMAL & AQUACULTURAL SCIENCES NORWEGIAN UNIV LIFE SCIENCES

RIVISTA

Royal Society Open Science, 3(5), 160030

IMPACT FACTOR

2,680

indietro