Pubblicazione scientifica

Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Summary

Tropodithietic acid (TDA) is a structurally unique sulfur-containing antibiotic from the Roseobacter clade bacterium Phaeobacter inhibens DSM 17395 and a few other related species. We have synthesised several structural analogues of TDA and used them in bioactivity tests against Staphylococcus aureus and Vibrio anguillarum for a structure–activity relationship (SAR) study, revealing that the sulfur-free analogue of TDA, tropone-2-carboxylic acid, has an antibiotic activity that is even stronger than the bioactivity of the natural product. The synthesis of this compound and of several analogues is presented and the bioactivity of the synthetic compounds is discussed.

DATA

Data di pubblicazione: 06/08/2014

AUTORI

RABE PATRICK
KLAPSCHINSKI TIM A
BROCK NELSON L
CITRON CHRISTIAN A
D’ALVISE PAUL
GRAM LONE
DICKSCHAT JEROEN S

ENTE DI AFFERENZA

KEKULE INST FUR ORGANISCHE CHEM RHEINISCHE FRIEDRICH WILHELMS UNIV BONN GERHARD DOMAGK STRA E 1 53121 BONN GERMANY
DEPT SYS BIOLOGY TECH UNIV DENMARK MATEMATIKTORVET BLDG 301 2800 KONGENS LYNGBY DENMARK

RIVISTA

Beilstein Journal of Organic Chemistry, 10, 1796-1801

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