Pubblicazione scientifica

Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which alter anxiety-like behavior in adult zebrafish. The observed phenotypes were clustered according to shared behavioral effects. This barcoding procedure revealed conserved functions of anxiolytic, anxiogenic and psychomotor stimulating drugs and predicted effects of poorly characterized compounds on anxiety. Moreover, anxiolytic drugs all decreased, while anxiogenic drugs increased, serotonin turnover. These results underscore the power of behavioral profiling in adult zebrafish as an approach which combines throughput and physiological complexity in the pharmacological dissection of complex behaviors.

DATA

Data di pubblicazione: 31/07/2014

AUTORI

MAXIMINO CAIO
DA SILVA ANNANDA WANEZA BATISTA
ARAUJO JULIANA
LIMA MONICA GOMES
MIRANDA VANESSA
PUTY BRUNA
BENZECRY RANCES
PICANCO-DINIZ DOMINGOS LUIZ WANDERLEY
GOUVEIA AMAURI JR
OLIVEIRA KAREN RENATA MATOS
HERCULANO ANDERSON MANOEL

ENTE DI AFFERENZA

Laboratório de Neurociências e Comportamento “Frederico Guilherme Graeff” Departamento de Morfologia e Ciências Fisiológicas Centro de Ciências Biológicas e da Saúde Universidade do Estado do Pará Marabá Pará Brazil
INST CIENCIAS BIOLOGICAS UNIV FEDERAL DO PARA BELEM PARA BRAZIL
LAB DE NEUROENDOCRINOLOGIA INST CIENCIAS BIOLOGICAS UNIV FEDERAL DO PARA BELEM PARA BRAZIL
UNIV FEDERAL DO OESTE DO PARA ORIXIMINA PARA BRAZIL
LAB DE NEUROCIENCIAS E COMPORTAMENTO NUCLEO DE PESQUISA E TEORIA DO COMPORTAMENTO UNIV FEDERAL DO PARA BELEM PARA BRAZIL
UNIV TORONTO MISSISSAUGA CANADA

RIVISTA

PLoS ONE, 9(7), e103943

IMPACT FACTOR

2,870

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