Pubblicazione scientifica

Diazepam and Fluoxetine Decrease the Stress Response in Zebrafish

FILONE TECNOLOGICO	TEMA
produzione e raccolta
trasformazione e commercializzazione

RIASSUNTO

The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.

DATA

Data di pubblicazione: 23/07/2014

AUTORI

DE ABREU MURILO SANDER
KOAKOSKI GESSI
FERREIRA DAIANE
OLIVEIRA THIAGO ACOSTA
DA ROSA JOAO GABRIEL SANTOS
GUSSO DARLAN
GIACOMINI ANA CRISTINA VARRONE
PIATO ANGELO LUIS
BARCELLOS LEONARDO JOSE GIL

ENTE DI AFFERENZA

PROGRAMA DE POS GRADUACAO EM FARMACOLOGIA UNIV FEDERAL DE SANTA MARIA UFSM SANTA MARIA RS BRASIL
UNIV PASSO FUNDO UPF PASSO FUNDO RS BRASIL
DEPARTAMENTO DE FARMACOLOGIA INST CIENCIAS BASICAS DA SAUDE UNIV FEDERAL DO RIO GRANDE DO SUL PORTO ALEGRE RS BRASIL
PROGRAMA DE POS GRADUACAO EM BIOEXPERIMENTACAO UNIV PASSO FUNDO UPF PASSO FUNDO RS BRASIL
UNIV NORTH CAROLINA AT CHAPEL HILL USA

RIVISTA

PLoS ONE, 9(7), e103232

IMPACT FACTOR

2,870

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