Pubblicazione scientifica

Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Nanoparticles have increasingly been used for a variety of applications, most notably for the delivery of therapeutic and diagnostic agents. A large number of nanoparticle drug delivery systems have been developed for cancer treatment and various materials have been explored as drug delivery agents to improve the therapeutic efficacy and safety of anticancer drugs. Natural biomolecules such as proteins are an attractive alternative to synthetic polymers which are commonly used in drug formulations because of their safety. In general, protein nanoparticles offer a number of advantages including biocompatibility and biodegradability. They can be prepared under mild conditions without the use of toxic chemicals or organic solvents. Moreover, due to their defined primary structure, protein-based nanoparticles offer various possibilities for surface modifications including covalent attachment of drugs and targeting ligands. In this paper, we review the most significant advancements in protein nanoparticle technology and their use in drug delivery arena. We then examine the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation. Finally, we discuss the applications of protein nanoparticles in cancer therapy.

DATA

Data di pubblicazione: 01/01/2014

AUTORI

LOHCHAROENKAL WARANGKANA
WANG LIYING
CHEN YI CHARLIE
ROJANASAKUL YON

ENTE DI AFFERENZA

DEPT PHARM SCIENCES WEST VIRGINIA UNIV MORGANTOWN WV 26506 USA
PATHOLOGY & PHYSIOLOGY RSCH BRANCH NATL INST OCCUPATIONAL SAFETY & HEALTH MORGANTOWN WV 26505 USA
NATURAL SCIENCE DIVISION ALDERSON BROADDUS COLLEGE PHILIPPI WV 26416 USA
MARY BABB RANDOLPH CANCER CTR WEST VIRGINIA UNIV MORGANTOWN WV 26506 USA

RIVISTA

BioMed Research International, 2014, 180549

IMPACT FACTOR

2,140

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