Pubblicazione scientifica

A Syntenic Region Conserved from Fish to Mammalian X Chromosome

FILONE TECNOLOGICO	TEMA
produzione e raccolta
trasformazione e commercializzazione

RIASSUNTO

Sex chromosomes bearing the sex-determining gene initiate development along the male or female pathway, no matter which sex is determined by XY male or ZW female heterogamety. Sex chromosomes originate from ancient autosomes but evolved rapidly after the acquisition of sex-determining factors which are highly divergent between species. In the heterogametic male system (XY system), the X chromosome is relatively evolutionary silent and maintains most of its ancestral genes, in contrast to its Y counterpart that has evolved rapidly and degenerated. Sex in a teleost fish, the Nile tilapia (Oreochromis niloticus), is determined genetically via an XY system, in which an unpaired region is present in the largest chromosome pair. We defined the differences in DNA contents present in this chromosome with a two-color comparative genomic hybridization (CGH) and the random amplified polymorphic DNA (RAPD) approach in XY males. We further identified a syntenic segment within this region that is well conserved in several teleosts. Through comparative genome analysis, this syntenic segment was also shown to be present in mammalian X chromosomes, suggesting a common ancestral origin of vertebrate sex chromosomes.

DATA

Data di pubblicazione: 01/01/2014

AUTORI

GUAN GUIJUN
YI MEISHENG
KOBAYASHI TOHRU
HONG YUNHAN
NAGAHAMA YOSHITAKA

ENTE DI AFFERENZA

KEY LAB
LAB OF REPRODUCTION NATL INST BASIC BIOLOGY OKAZAKI AICHI 444 8585 JAPAN
LAB OF MOLECULAR REPRODUCTIVE BIOLOGY SCHOOL OF MARINE SCIENCES SUN YAT SEN UNIV
LAB OF MOLECULAR DEV BIOLOGY INST ENVIRONMENTAL SCIENCES UNIV SHIZUOKA YADA SHIZUOKA 422 8526 JAPAN
DEPT BIOLOGICAL SCIENCES NATL UNIV SINGAPORE
SOUTH EHIME FISHERIES RSCH CTR INST COLLABORATIVE RELATIONS EHIME UNIV

RIVISTA

International Journal of Evolutionary Biology, 2014, 873935

IMPACT FACTOR

1,91

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