Pubblicazione scientifica

Mercury, Autoimmunity, and Environmental Factors on Cheyenne River Sioux Tribal Lands

FILONE TECNOLOGICO	TEMA
produzione e cattura
trasformazione e commercializzazione

RIASSUNTO

Mercury (Hg), shown to induce autoimmune disease in rodents, is a ubiquitous toxicant throughout Cheyenne River Sioux Tribe (CRST) lands. CRST members may be exposed to Hg through fish consumption (FC), an important component of native culture that may supplement household subsistence. Our goals were to ascertain whether total blood Hg levels (THg) reflect Hg exposure through FC and smoking, and determine whether THg is associated with the presence of anti-nuclear antibody (ANA) and specific autoantibodies (sAuAb). We recruited 75 participants who regularly consume fish from CRST waters. Hg exposure through FC and smoking were assessed via questionnaires. Whole blood samples were collected from participants, and THg was measured using ICP-MS. ANA and sAuAb in serum were modeled using demographic and exposure information as predictors. Female gender, age, and FC were significant predictors of THg and sAuAb; self-reported smoking was not. 31% of participants tested positive for ANA ≥ 2+. Although ANA was not significantly associated with Hg, the interactions of gender with Hg and proximity to arsenic deposits were statistically significant (P < 0.05). FC resulted in a detectable body burden of Hg, but THg alone did not correlate with the presence of ANA or sAuAb in this population.

DATA

Data di pubblicazione: 01/01/2014

AUTORI

ONG JENNIFER
ERDEI ESTHER
RUBIN ROBERT L
MILLER CURTIS
DUCHENEAUX CARLYLE
OLEARY MARCIA
PACHECO BERNADETTE
MAHLER MICHAEL
HENDERSON PATRICIA NEZ
POLLARD K MICHAEL
LEWIS JOHNNYE L

ENTE DI AFFERENZA

COLLEGE OF PHARMACY COMMUNITY ENVIRONMENTAL HEALTH PROGRAM UNIV NEW MEXICO HEALTH SCIENCES CTR 905 VASSAR NE ALBUQUERQUE NM 87106 USA
SCHOOL OF MEDICINE UNIV NEW MEXICO HEALTH SCIENCES CTR 1 UNIV NEW MEXICO ALBUQUERQUE NM 87131 USA
DEPT NATURAL RESOURCES CHEYENNE RIVER SIOUX TRIBE
MISSOURI BREAKS IND RSCH INC
INOVA DIAGNOSTICS INC
BLACK HILLS CTR AMERICAN INDIAN HEALTH
SCRIPPS RSCH INST

RIVISTA

Autoimmune Diseases, 2014, 325461

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