Pubblicazione scientifica

Tributyltin and Zebrafish: Swimming in Dangerous Water

FILONE TECNOLOGICO	TEMA
economia circolare e sostenibilità
produzione e cattura

RIASSUNTO

Zebrafish has been established as a reliable biological model with important insertion in academy (morphologic, biochemical, and pathophysiological studies) and pharmaceutical industry (toxicology and drug development) due to its molecular complexity and similar systems biology that recapitulate those from other organisms. Considering the toxicological aspects, many efforts using zebrafish models are being done in order to elucidate the effects of endocrine disruptors, and some of them are focused on tributyltin (TBT) and its mechanism of action. TBT is an antifouling agent applied in ship’s hull that is constantly released into the water and absorbed by marine organisms, leading to bioaccumulation and biomagnification effects. Thus, several findings of malformations and changes in the normal biochemical and physiologic aspects of these marine animals have been related to TBT contamination. In the present review, we have compiled the most significant studies related to TBT effects in zebrafish, also taking into consideration the effects found in other study models.

DATA

Data di pubblicazione: 10/04/2018

AUTORI

BERTO-JUNIOR CLEMILSON
DE CARVALHO DENISE PIRES
SOARES PAULA
MIRANDA-ALVES LEANDRO

ENTE DI AFFERENZA

Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) – Cancer Signaling and Metabolism Porto Portugal
GRUPO DE PESQUISA DESENVOLVIMENTO E INOVACAO EM ENDOCRINOLOGIA EXPERIMENTAL GPDIEEX INST CIENCIAS BIOMEDICAS UNIV FEDERAL DO RIO DE JANEIRO RIO DE JANEIRO BRAZIL
LAB INTEGRADO DE CIENCIAS FARMA LICFAR UNIV FEDERAL DO RIO DE JANEIRO RIO DE JANEIRO BRAZIL
ENDOCRINOLOGIA FACULDADE DE MEDICINA UNIV FEDERAL DO RIO DE JANEIRO RIO DE JANEIRO BRAZIL
LAB DE FISIOLOGIA ENDOCRINA DORIS ROSENTHAL INST BIOFISICA CARLOS CHAGAS FILHO UNIV FEDERAL DO RIO DE JANEIRO RIO DE JANEIRO BRAZIL
INST INVESTIGACAO E INOVACAO EM SAUDE I3S UNIV DO PORTO PORTO PORTUGAL
FACULDADE DE MEDICINA UNIV DO PORTO PORTO PORTUGAL
DEPARTAMENTO DE PATOLOGIA FACULDADE DE MEDICINA UNIV DO PORTO PORTO PORTUGAL
FARMACOLOGIA E QUIM MEDICINAL INST CIENCIAS BIOMEDICAS UNIV FEDERAL DO RIO DE JANEIRO RIO DE JANEIRO BRAZIL

RIVISTA

Frontiers in Endocrinology, 9, 152

IMPACT FACTOR

3,630

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