Pubblicazione scientifica

Antibody responses to Schistosoma mansoni schistosomula antigens

FILONE TECNOLOGICO	TEMA
produzione e cattura

RIASSUNTO

Summary

While antigens from Schistosoma schistosomula have been suggested as potential vaccine candidates, the association between antibody responses with schistosomula antigens and infection intensity at reinfection is not well known. Schistosoma mansoni‐infected individuals were recruited from a schistosomiasis endemic area in Uganda (n = 372), treated with 40 mg/kg praziquantel ( PZQ) and followed up at five weeks and at one year post‐treatment. Pre‐treatment and five weeks post‐treatment immunoglobulin (Ig) E, IgG1 and IgG4 levels against recombinant schistosomula antigens rSmKK7, rSmLy6A, rSmLy6B and rSmTSP7 were measured using ELISA. Factors associated with detectable pre‐treatment or post‐treatment antibody response against the schistosomula antigens and the association between five‐week antibody responses and one year post‐treatment reinfection intensity among antibody responders were examined. Being male was associated with higher pre‐treatment IgG1 to rSmKK7, rSmLy6a and AWA. Five weeks post‐treatment antibody responses against schistosomula antigens were not associated with one year post‐treatment reinfection intensity among antibody responders’ antibody levels against rSmKK7, rSmLy6B and rSmTSP7 dropped, but increased against rSmLy6A, AWA and SEA at five weeks post‐treatment among antibody responders. S. mansoni‐infected individuals exhibit detectable antibody responses to schistosomula antigens that are affected by treatment. These findings indicate that schistosomula antigens induce highly varied antibody responses and could have implications for vaccine development.

DATA

Data di pubblicazione: 14/10/2018

AUTORI

EGESA MOSES
LUBYAYI LAWRENCE
JONES FRANCES M
VAN DIEPEN ANGELA
CHALMERS IAIN W
TUKAHEBWA EDRIDAH M
BAGAYA BERNARD S
HOKKE CORNELIS H
HOFFMANN KARL F
DUNNE DAVID W
ELLIOTT ALISON M
YAZDANBAKHSH MARIA
WILSON SHONA
COSE STEPHEN

ENTE DI AFFERENZA

DEPT MEDICAL MICROBIOLOGY SCHOOL OF BIOMEDICAL SCIENCES MAKERERE UNIV COLLEGE OF HEALTH SCIENCES KAMPALA UGANDA
MEDICAL RSCH COUNCIL UGANDA VIRUS RSCH INST & LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE UGANDA RSCH UNIT ENTEBBE UGANDA
DEPT PATHOLOGY UNIV CAMBRIDGE CAMBRIDGE UK
DEPT PARASITOLOGY LEIDEN UNIV MEDICAL CTR LEIDEN NETHERLANDS
INST BIOLOGICAL ENVIRONMENTAL & RURAL SCIENCES ABERYSTWYTH UNIV ABERYSTWYTH UK
VECTOR CTRL DIVISION MINST HEALTH KAMPALA UGANDA
DEPT IMMUNOLOGY & MOLECULAR BIOLOGY SCHOOL OF BIOMEDICAL SCIENCES MAKERERE UNIV COLLEGE OF HEALTH SCIENCES KAMPALA UGANDA
DEPT CLINICAL RSCH LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE LONDON UK

RIVISTA

Parasite Immunology, 40(12), e12591

IMPACT FACTOR

2,090

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