Pesca Pubblicazione scientifica Complex virome in feces from Amerindian children in isolated Amazonian villages FILONE TECNOLOGICO TEMA produzione e cattura RIASSUNTO The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contact. Numerous human enteric viruses, mainly from the Picornaviridae and Caliciviridae families, were sequenced from each of the sites. Multiple children from the same villages shed closely related viruses reflecting frequent transmission clusters. Feces of isolated villagers also contained multiple viral genomes of unknown cellular origin from the Picornavirales order and CRESS-DNA group and higher levels of nematode and protozoan DNA. Despite cultural and geographic isolation, the diversity of enteric human viruses was therefore not reduced in these Amazonian villages. Frequent viral introductions and/or increased susceptibility to enteric infections may account for the complex fecal virome of Amerindian children in isolated villages. DATA Data di pubblicazione: 15/10/2018 AUTORI SIQUEIRA JULIANA D DOMINGUEZ-BELLO MARIA GLORIA CONTRERAS MONICA LANDER ORLANA CABALLERO-ARIAS HORTENSIA XUTAO DENG NOYA-ALARCON OSCAR DELWART ERIC RIVISTA Nature Communications, 9, 4270