Pubblicazione scientifica

Omega-3 Polyunsaturated Fatty Acids and Stroke Burden

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Greenland Eskimo population, whose diet is high in marine n-3 PUFAs, have a lower incidence of coronary heart disease than Western populations, numerous epidemiological studies to explore the associations of dietary intakes of fish and n-3 PUFAs with cardiovascular diseases, and large-scale clinical trials to identify the benefits of treatment with n-3 PUFAs have been conducted. In most of these studies the incidence and mortality of stroke were also evaluated mainly as secondary endpoints. Thus, a systematic literature review regarding the association of dietary intake of n-3 PUFAs with stroke in the epidemiological studies and the treatment effects of n-3 PUFAs in the clinical trials was conducted. Moreover, recent experimental studies were also reviewed to explore the molecular mechanisms of the neuroprotective effects of n-3 PUFAs after stroke.

DATA

Data di pubblicazione: 07/11/2019

AUTORI

UENO YUJI
MIYAMOTO NOBUKAZU
YAMASHIRO KAZUO
TANAKA RYOTA
HATTORI NOBUTAKA

ENTE DI AFFERENZA

DEPT NEUROLOGY JUNTENDO UNIV FACULTY OF MEDICINE TOKYO 113 8421 JAPAN NOBU M JUNTENDO AC JP NM KAZUO Y JUNTENDO AC JP KY NHATTORI JUNTENDO AC JP NH
STROKE CTR

RIVISTA

International Journal of Molecular Sciences, 20(22), 5549

IMPACT FACTOR

4,210

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