Pubblicazione scientifica

Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Oxidative stress can be induced by mercury (Hg) exposure, including through fish consumption (diet), leading to health risks. The objective of this study was to evaluate the association between oxidative stress biomarkers and dietary Hg exposure levels in riverine children and adolescents at Madeira River (RO/Brazil). Population from three riverine local communities presenting different fish consumption frequencies was sampled. Hg was determined in blood (ICP-MS) and glutathione (GSH); glutathione S-transferases (GST) and malondialdehyde (MDA) were determined in serum (spectrophotometry). Statistical analyses were performed using parametric and non-parametric tests. Multiple linear regression models and generalized additives models were also used to estimate the relationships between oxidative stress biomarkers and blood Hg. The juvenile riverine population from Cuniã RESEX presented the highest levels of oxidative stress and Hg levels in blood (GST = 27.2 (4.93) U/L, MDA = 1.69 (0.27) µmol/L, Hg = 20.6 (18.0) µg/L). This population also presented the highest frequency of fish consumption. The positive relation between Hg and GST and MDA, adjusted for individual characteristics, suggests an oxidative effect. This study shows the importance of oxidative stress biomarkers in the evaluation of dietary Hg exposure since initial and reversible metabolic changes were observed, enriching health risk assessments.

DATA

Data di pubblicazione: 27/07/2019

AUTORI

CARVALHO LEANDRO VB
HACON SANDRA S
VEGA CLAUDIA M
VIEIRA JUCILENE A
LARENTIS ARIANE L
MATTOS RITA C O C
VALENTE DANIEL
COSTA-AMARAL ISABELE C
MOURAO DENNYS S
SILVA GABRIELA P
OLIVEIRA BEATRIZ F A

ENTE DI AFFERENZA

TOXICOLOGY LABORATORY CENTER FOR STUDIES OF WORKER’S HEALTH AND HUMAN ECOLOGY CESTEH NATIONAL SCHOOL OF PUBLIC HEALTH SERGIO AROUCA ENSP OSWALDO CRUZ FOUNDATION FIOCRUZ LEOPOLDO BULHOES STREET 1480 MANGUINHOS RIO DE JANEIRO-RJ CEP 21041-210 BRAZIL
DEPT ENDEMICS SAMUEL PESSOA DENSP NATL SCHOOL OF PUBLIC HEALTH SERGIO AROUCA ENSP OSWALDO CRUZ FNDN FIOCRUZ LEOPOLDO
CTR INNOVACCION CIENTIFICA AMAZONICA CINCIA JR CAJAMARCA C

RIVISTA

International Journal of Environmental Research and Public Health, 16(15), 2682

IMPACT FACTOR

2,620

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