Pubblicazione scientifica

Omega-3 Fatty Acids-Enriched Fish Oil Activates AMPK/PGC-1α Signaling and Prevents Obesity-Related Skeletal Muscle Wasting

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Obesity is known to cause skeletal muscle wasting. This study investigated the effect and the possible mechanism of fish oil on skeletal muscle wasting in an obese rat model. High-fat (HF) diets were applied to induce the defects of lipid metabolism in male Sprague-Dawley rats with or without substitution of omega-3 fatty acids-enriched fish oil (FO, 5%) for eight weeks. Diets supplemented with 5% FO showed a significant decrease in the final body weight compared to HF diet-fed rats. The decreased soleus muscle weights in HF diet-fed rats could be improved by FO substitution. The decreased myosin heavy chain (a muscle thick filament protein) and increased FOXO3A and Atrogin-1 (muscle atrophy-related proteins) protein expressions in soleus muscles of HF diet-fed rats could also be reversed by FO substitution. FO substitution could also significantly activate adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation, peroxisome-proliferator-activated receptor-γ (PPARγ) coactivator 1α (PGC-1α), and PPARγ protein expression and lipoprotein lipase (LPL) mRNA expression in soleus muscles of HF diet-fed rats. These results suggest that substitution of FO exerts a beneficial improvement in the imbalance of lipid and muscle metabolisms in obesity. AMPK/PGC-1α signaling may play an important role in FO-prevented obesity-induced muscle wasting.

DATA

Data di pubblicazione: 25/06/2019

AUTORI

LIU SHING-HWA
CHIU CHEN-YUAN
WANG LOU-PIN
CHIANG MENG-TSAN

ENTE DI AFFERENZA

GRADUATE INST TOXICOLOGY COLLEGE OF MEDICINE NATL TAIWAN UNIV TAIPEI 100 TAIWAN SHINGHWALIU NTU EDU TW
DEPT PEDIATRICS COLLEGE OF MEDICINE & HOSPITAL NATL TAIWAN UNIV TAIPEI 100 TAIWAN
DEPT MEDICAL RSCH CHINA MEDICAL UNIV HOSPITAL CHINA MEDICAL UNIV TAICHUNG 404 TAIWAN
INST FOOD SAFETY & HEALTH COLLEGE OF PUBLIC HEALTH NATL TAIWAN UNIV TAIPEI 100 TAIWAN CHENYUANCHIU NTU EDU TW
DEPT FOOD SCIENCE COLLEGE OF LIFE SCIENCE NATL TAIWAN OCEAN UNIV KEELUNG 202 TAIWAN GMOV2504 GMAIL COM

RIVISTA

Marine Drugs, 17(6), 380

IMPACT FACTOR

3,810

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