Pubblicazione scientifica

Optimizing Genomic Prediction of Host Resistance to Koi Herpesvirus Disease in Carp

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Genomic selection (GS) is increasingly applied in breeding programs of major aquaculture species, enabling improved prediction accuracy and genetic gain compared to pedigree-based approaches. Koi Herpesvirus disease (KHVD) is notifiable by the World Organization for Animal Health and the European Union, causing major economic losses to carp production. GS has potential to breed carp with improved resistance to KHVD, thereby contributing to disease control. In the current study, Restriction-site Associated DNA sequencing (RAD-seq) was applied on a population of 1,425 common carp juveniles which had been challenged with Koi herpes virus, followed by sampling of survivors and mortalities. GS was tested on a wide range of scenarios by varying both SNP densities and the genetic relationships between training and validation sets. The accuracy of correctly identifying KHVD resistant animals using GS was between 8 and 18% higher than pedigree best linear unbiased predictor (pBLUP) depending on the tested scenario. Furthermore, minor decreases in prediction accuracy were observed with decreased SNP density. However, the genetic relationship between the training and validation sets was a key factor in the efficacy of genomic prediction of KHVD resistance in carp, with substantially lower prediction accuracy when the relationships between the training and validation sets did not contain close relatives.

DATA

Data di pubblicazione: 12/06/2019

AUTORI

PALAIOKOSTAS CHRISTOS
VESELY TOMAS
KOCOUR MARTIN
PRCHAL MARTIN
POKOROVA DAGMAR
PIACKOVA VERONIKA
POJEZDAL LUBOMIR
HOUSTON ROSS D

ENTE DI AFFERENZA

ROYAL DICK SCHOOL OF VETERINARY STUDIES ROSLIN INST UNIV EDINBURGH MIDLOTHIAN UK
DEPT ANIMAL BREEDING & GENETICS SWEDISH UNIV AGRICULTURAL SCIENCES UPPSALA SWEDEN
VETERINARY RSCH INST BRNO CZECHIA
FACULTY OF FISHERIES AND PROTECTION OF WATERS SOUTH BOHEMIAN RESEARCH CENTRE OF AQUACULTURE AND BIODIVERSITY OF HYDROCENOSES UNIVERSITY OF SOUTH BOHEMIA CESKE BUDEJOVICE VODNANY CZECHIA

RIVISTA

Frontiers in Genetics, 10, 543

IMPACT FACTOR

3,360

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