Pubblicazione scientifica

The three-spined stickleback as a model for behavioural neuroscience

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

The three-spined stickleback (Gasterosteus aculeatus) is a small teleost fish that is ubiquitous across the Northern Hemisphere. Among the behaviours that have been characterised in this species is ritualized courtship, aggressiveness and parental behaviour. Whereas three-spined sticklebacks have been used for ecological, evolutionary, parasitological and toxicological research, its complex behavioural repertoire and experimental advantages have not been exploited for basic neuroscience research. The aim of the present study is to describe some innate behaviours of laboratory bred three-spined sticklebacks by using a battery of tests that have been developed and validated to model some aspects of human psychiatric disorders in zebrafish. We recorded mirror induced aggression, novel object boldness, shoaling, and anxiety-like behaviour using both the novel tank diving and the black-white preference tests. We show that behaviour of three-spined sticklebacks in these standard tests is remarkably similar to that of zebrafish and other species and can be altered by fluoxetine and buspirone. These findings highlight the potential of using three-spined sticklebacks for cross-species and translational studies.

DATA

Data di pubblicazione: 26/03/2019

AUTORI

NORTON WILLIAM H J
GUTIERREZ HECTOR CARRENO

ENTE DI AFFERENZA

DEPT NEUROSCIENCE PSYCHOLOGY & BEHAVIOUR COLLEGE OF LIFE SCIENCES UNIV LEICESTER LEICESTER UK
UNIV ZURICH SWITZERLAND

RIVISTA

PLoS ONE, 14(3), e0213320

IMPACT FACTOR

2,870

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