Pubblicazione scientifica

High-Load Reovirus Infections Do Not Imply Physiological Impairment in Salmon

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

The recent ubiquitous detection of PRV among salmonids has sparked international concern about the cardiorespiratory performance of infected wild and farmed salmon. Piscine orthoreovirus (PRV) has been shown to create substantial viremia in salmon by targeting erythrocytes for principle replication. In some instances, infections develop into heart and skeletal muscle inflammation (HSMI) or other pathological conditions affecting the respiratory system. Critical to assessing the seriousness of PRV infections are controlled infection studies that measure physiological impairment to critical life support systems. Respiratory performance is such a system and here multiple indices were measured to test the hypothesis that a low-virulence strain of PRV from Pacific Canada compromises the cardiorespiratory capabilities of Atlantic salmon. Contrary to this hypothesis, the oxygen affinity and carrying capacity of erythrocytes were unaffected by PRV despite the presence of severe viremia, minor heart pathology and transient cellular activation of antiviral response pathways. Similarly, PRV-infected fish had neither sustained nor appreciable differences in respiratory capabilities compared with control fish. The lack of functional harm to salmon infected with PRV in this instance highlights that, in an era of unprecedented virus discovery, detection of viral infection does not necessarily imply bodily harm and that viral load is not always a suitable predictor of disease within a host organism.

DATA

Data di pubblicazione: 13/03/2019

AUTORI

ZHANG YANGFAN
POLINSKI MARK P
MORRISON PHILLIP R
BRAUNER COLIN J
FARRELL ANTHONY P
GARVER KYLE A

ENTE DI AFFERENZA

FACULTY OF LAND & FOOD SYS UNIV BRITISH COLUMBIA VANCOUVER BC CANADA
AQUATIC DIAGNOSTICS & GENOMICS DIVISION PACIFIC BIOLOGICAL STATION FISHERIES & OCEANS CANADA NANAIMO BC CANADA
DEPT ZOOLOGY UNIV BRITISH COLUMBIA VANCOUVER BC CANADA

RIVISTA

Frontiers in Physiology, 10, 114

IMPACT FACTOR

3,160

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