Pubblicazione scientifica

Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

The general understanding has been that only adaptive immunity is capable of immunological memory, but this concept has been challenged in recent years by studies showing that innate immune systems can mount resistance to reinfection—as the innate immune system can adapt its function following an insult. Innate immune training offers an attractive approach in intensive fish larval rearing, especially since the adaptive immune system is not fully developed. Trained innate immunity will potentially favor robust fish in terms of resistance to viral and bacterial diseases. So-called immunostimulants such as ß-glucans have for decades been used both in laboratories and in intensive fish aquaculture. Treatment of fish by ß-glucans (and by other substances with pathogen-associated molecular patterns) often induces activation of non-specific/innate immune mechanisms and induces higher disease resistance. The reported effects of e.g., ß-glucans fit nicely into the concept “trained innate immunity,” but the research on fish does not yet include analysis of epigenetic changes that may be a prerequisite for long-lasting trained innate immunity. In this “perspective,” we will discuss how in practical terms and based on prior knowledge one can introduce innate immune training in brood stock fish, and their offspring, and whether innate immune training by ß-glucans is a viable approach in larval aquaculture.

DATA

Data di pubblicazione: 25/01/2019

AUTORI

ZHANG ZUOBING
CHI HENG
DALMO ROY A

ENTE DI AFFERENZA

SCHOOL OF LIFE SCIENCE SHANXI UNIV TAIYUAN CHINA
KEY LAB OF EXPERIMENTAL MARINE BIOLOGY INST OCEANOLOGY CHINESE ACAD SCIENCES QINGDAO CHINA
RESEARCH GROUP AQUACULTURE AND ENVIRONMENT NORWEGIAN COLLEGE OF FISHERY SCIENCE FACULTY OF BIOSCIENCES FISHERIES AND ECONOMY UNIVERSITY OF TROMSO—THE ARCTIC UNIVERSITY OF NORWAY TROMSO NORWAY

RIVISTA

Frontiers in Immunology, 10, 42

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