Pubblicazione scientifica

Assessment of high-fat-diet-induced fatty liver in medaka

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

ABSTRACT

Fatty liver, which has been continuously becoming more common in a number of patients, is the most common liver disease. For detailed analysis, a useful model for fatty liver is needed and fish are considered as a potential candidate. We assessed through direct observation of the liver, which is the most conventional method for non-invasive analysis of progression in fatty liver. By using transparent medaka (Oryzias latipes), we were able to observe changes in fat deposition in the liver. An analysis of the progression of fatty liver using ultrasound showed a significant increase in echo intensity, which indicates that this is a useful examination method. In addition, we clarified a metabolite profile in the medaka liver fed a high-fat diet (HFD), which had not previously been shown in detail. This medaka model, allowing non-invasive and repetitive assessment, is a useful model for the analysis of diseases that cause fatty liver in which changes in detailed metabolites are identified.

DATA

Data di pubblicazione: 15/11/2018

AUTORI

FUJISAWA KOICHI
TAKAMI TARO
FUKUI YUMI
NAGATOMO TAKAHIRO
SAEKI ISSEI
MATSUMOTO TOSHIHIKO
HIDAKA ISAO
YAMAMOTO NAOKI
OKAMOTO TAKESHI
FURUTANI-SEIKI MAKOTO
SAKAIDA ISAO

ENTE DI AFFERENZA

CTR REGENERATIVE MEDICINE YAMAGUCHI UNIV SCHOOL OF MEDICINE 1 1 1 MINAMI KOGUSHI UBE YAMAGUCHI 755 8505 JAPAN
DEPT GASTROENTEROLOGY & HEPATOLOGY YAMAGUCHI UNIV GRADUATE SCHOOL OF MEDICINE 1 1 1 MINAMI KOGUSHI UBE YAMAGUCHI 755 8505 JAPAN
SYSTEMS BIOCHEMISTRY IN PATHOLOGY & REGENERATION YAMAGUCHI UNIV GRADUATE SCHOOL OF MEDICINE 1 1 1 MINAMI KOGUSHI UBE YAMAGUCHI 755 8505 JAPAN

RIVISTA

Biology Open, 7(11), bio031534

IMPACT FACTOR

1,980

indietro