Pubblicazione scientifica

Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Hair growth is regulated by the interaction between dermal papilla cells (DPC) and other cells inside the hair follicle. Here, we show the effect and action mechanism of mackerel-derived fermented fish oil (FFO) extract and its component docosahexaenoic acid (DHA) in the control of hair growth. The hair growth effect of FFO extract was evaluated by the culture method of vibrissa follicles and in vivo dotmatrix planimetry method. FFO extract increased the length of hair-fibers and enabled stimulated initiation into the anagen phase of the hair cycle. As expected, FFO extract significantly increased DPC proliferation. FFO extract induced the progression of the cell cycle and the activation of extracellular signal-regulated kinase (ERK), p38 and Akt. FFO extract induced nuclear translocation of β-catenin, a stimulator of anagen phase, through an increase of phospho-glycogen synthase kinase3β (GSK3β) level. Since various prostaglandins are known to promote hair growth in humans and mice, we examined the effect of DHA, a main omega-3 fatty acid of FFO, on DPC proliferation. DHA not only increased DPC proliferation but also upregulated levels of cell cycle-associated proteins such as cyclin D1 and cdc2 p34. These results show that FFO extract and DHA promote hair growth through the anagen-activating pathways in DPC.

DATA

Data di pubblicazione: 14/09/2018

AUTORI

KANG JUNG-IL
YOON HOON-SEOK
KIM SUNG MIN
PARK JEONG EON
HYUN YU JAE
KO ARA
AHN YONG-SEOK
KOH YOUNG SANG
HYUN JIN WON
YOO EUN-SOOK
KANG HEE-KYOUNG

ENTE DI AFFERENZA

DEPT MEDICINE SCHOOL OF MEDICINE JEJU NATL UNIV 102 JEJUDAEHAKNO JEJU 63243 KOREA JIKANG0024 JEJUNU AC KR J IK HSYOON717 JEJUNU AC KR H SY SEONGMIN85 NAVER COM SMK JEONGEON7780 HANMAIL NET JEP YUJAE1113 JEJUNU AC KR YJH RHDKFK0123 NAVER COM AK YSKOH7 JEJUNU AC KR YSK JINWONH JEJUNU AC KR JWH EUNSYOO JEJUNU AC KR E SY
CHOUNG RYONG FISHERIES CO LTD
JEJU RSCH CTR NATURAL MEDICINE JEJU NATL UNIV 102 JEJUDAEHAKNO JEJU 63243 KOREA

RIVISTA

International Journal of Molecular Sciences, 19(9), 2770

IMPACT FACTOR

4,210

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