Pubblicazione scientifica

Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms

FILONE TECNOLOGICO	TEMA
economia circolare e sostenibilità	efficientamento energetico e sostenibilità delle operazioni in mare
produzione e cattura	modalità di utilizzo delle reti/attrezzi da pesca
trasformazione e commercializzazione	certificazione e marchi di qualità sistemi di packaging, etichettatura e conservazione dei prodotti

RIASSUNTO

The changing of omega-6/omega-3 polyunsaturated fatty acids (PUFA) in the food supply of Western societies occurred over the last 150 years is thought to promote the pathogenesis of many inflammatory-related diseases, including depressive disorders. Several epidemiological studies reported a significant inverse correlation between intake of oily fish and depression or bipolar disorders. Studies conducted specifically on the association between omega-3 intake and depression reported contrasting results, suggesting that the preventive role of omega-3 PUFA may depend also on other factors, such as overall diet quality and the social environment. Accordingly, tertiary prevention with omega-3 PUFA supplement in depressed patients has reached greater effectiveness during the last recent years, although definitive statements on their use in depression therapy cannot be yet freely asserted. Among the biological properties of omega-3 PUFA, their anti-inflammatory effects and their important role on the structural changing of the brain should be taken into account to better understand the possible pathway through which they can be effective both in preventing or treating depression. However, the problem of how to correct the inadequate supply of omega-3 PUFA in the Westernized countries' diet is a priority in order to set food and health policies and also dietary recommendations for individuals and population groups.

DATA

Data di pubblicazione: 01/01/2014

AUTORI

GROSSO GIUSEPPE
GALVANO FABIO
MARVENTANO STEFANO
MALAGUARNERA MICHELE
BUCOLO CLAUDIO
DRAGO FILIPPO
CARACI FILIPPO

ENTE DI AFFERENZA

Department of “G.F. Ingrassia” Section of Hygiene and Public Health University of Catania Via S. Sofia 85 95123 Catania Italy
DEPT CLINICAL & MOLECULAR BIOMEDICINE SECTION OF PHARMACOLOGY & BIOCHEMISTRY UNIV CATANIA
DEPT EDUCATIONAL SCIENCES UNIV CATANIA
IRCCS ASSOC OASI MARIA SS INST RSCH ON MENTAL RETARDATION & BRAIN AGING

RIVISTA

Oxidative Medicine and Cellular Longevity, 2014, 313570

IMPACT FACTOR

4,580

indietro