Pubblicazione scientifica

Identification of Trombospondin-1 as a Novel Amelogenin Interactor by Functional Proteomics

FILONE TECNOLOGICO	TEMA
produzione e cattura	modalità di utilizzo delle reti/attrezzi da pesca sistemi di individuazione sottomarini (es. ecoscandaglio, ecc.)

RIASSUNTO

Amelogenins are a set of low molecular-weight enamel proteins belonging to a group of extracellular matrix (ECM) proteins with a key role in tooth enamel development and in other regeneration processes, such as wound healing and angiogenesis. Since only few data are actually available to unravel amelogenin mechanism of action in chronic skin healing restoration, we moved to the full characterization of the human amelogenin isoform 2 interactome in the secretome and lysate of Human Umbilical Vein Endothelial cells (HUVEC), using a functional proteomic approach. Trombospondin-1 has been identified as a novel and interesting partner of human amelogenin isoform 2 and their direct binding has been validated thought biophysical orthogonal approaches.

DATA

Data di pubblicazione: 09/10/2017

AUTORI

CAPOLUPO ANGELA
CASSIANO CHIARA
CASAPULLO AGOSTINO
ANDREOTTI GIUSEPPINA
CUBELLIS MARIA V
RICCIO ANDREA
RICCIO RAFFAELE
MONTI MARIA C

ENTE DI AFFERENZA

DEPT PHARMACY UNIV SALERNO SALERNO ITALY
PHD PROGRAM IN DRUG DISCOVERY & DEV UNIV SALERNO SALERNO ITALY
INST DI CHIM BIOMOLECOLARE CONSIGLIO NATL DELLE RICERCHE CNR NAPOLI ITALY
DEPT BIOLOGY UNIV NAPLES FEDERICO II NAPOLI ITALY
DEPT ENVIRONMENTAL BIOLOGICAL & PHARM SCIENCES & TECH UNIV CIA LUIGI VANVITELLI CASERTA ITALY

RIVISTA

Frontiers in Chemistry, 5, 74

IMPACT FACTOR

3,420

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