Pubblicazione scientifica

Senescence gives insights into the morphogenetic evolution of anamniotes

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

ABSTRACT

Senescence represents a mechanism to avoid undesired cell proliferation that plays a role in tumor suppression, wound healing and embryonic development. In order to gain insight on the evolution of senescence, we looked at its presence in developing axolotls (urodele amphibians) and in zebrafish (teleost fish), which are both anamniotes. Our data indicate that cellular senescence is present in various developing structures in axolotls (pronephros, olfactory epithelium of nerve fascicles, lateral organs, gums) and in zebrafish (epithelium of the yolk sac and in the lower part of the gut). Senescence was particularly associated with transient structures (pronephros in axolotls and yolk sac in zebrafish) suggesting that it may play a role in the elimination of these tissues. Our data supports the notion that cellular senescence evolved early in vertebrate evolution to influence embryonic development.

DATA

Data di pubblicazione: 12/05/2017

AUTORI

VILLIARD ERIC
DENIS JEAN-FRANCOIS
HASHEMI FARANAK SADAT
IGELMANN SEBASTIAN
FERBEYRE GERARDO
ROY STEPHANE

ENTE DI AFFERENZA

DEPT STOMATOLOGY FACULTY OF DENTISTRY UNIV MONTREAL MONTREAL QUEBEC H3T 1J4 CANADA
DEPT BIOCHEMISTRY & MOLECULAR MEDICINE FACULTY OF MEDICINE UNIV MONTREAL MONTREAL QUEBEC H3T 1J4 CANADA

RIVISTA

Biology Open, 6(6), 891-896

IMPACT FACTOR

1,980

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