Pubblicazione scientifica

Premammalian origin of the sperm‐specific Slo3 channel

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Slo3 is a sperm‐specific potassium (K+) channel essential for male fertility. Slo3 channels have so far been considered to be specific to mammals. Through exploratory genomics, we identified the Slo3 gene in the genome of terrestrial (birds and reptiles) and aquatic (fish) vertebrates. In the case of fish, Slo3 has undergone several episodes of gene loss. Transcriptomic analysis showed that vertebrate Slo3 transcript orthologues are predominantly expressed in testis, in concordance with the mammalian Slo3. We conclude that the Slo3 gene arose during the radiation of early vertebrates, much earlier than previously thought. Our findings add to the growing evidence indicating that the phylogenetic profiles of sperm‐specific channels are intermittent throughout metazoan evolution, which probably reflects the adaptation of sperm to different ionic milieus and fertilization environments.

DATA

Data di pubblicazione: 17/02/2017

AUTORI

VICENS ALBERTO
ANDRADE‐LOPEZ KARLA
CORTEZ DIEGO
GUTIERREZ ROSA MARIA
TREVINO CLAUDIA L

ENTE DI AFFERENZA

DEPARTAMENTO DE GENETICA DEL DESARROLLO Y FISIOLOGIA MOLECULAR INST BIOTECNOLOGIA UNIV NATL AUTONOMA DE MEXICO CUERNAVACA MORELOS MEXICO
CTR CIENCIAS GENOMICAS UNIV NATL AUTONOMA DE MEXICO CUERNAVACA MORELOS MEXICO
DEPARTAMENTO DE MICROBIOLOGIA MOLECULAR INST BIOTECNOLOGIA UNIV NATL AUTONOMA DE MEXICO CUERNAVACA MORELOS MEXICO

RIVISTA

FEBS Open Bio, 7(3), 382-390

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