Pubblicazione scientifica

Temperature-induced cardiac remodelling in fish

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

ABSTRACT

Thermal acclimation causes the heart of some fish species to undergo significant remodelling. This includes changes in electrical activity, energy utilization and structural properties at the gross and molecular level of organization. The purpose of this Review is to summarize the current state of knowledge of temperature-induced structural remodelling in the fish ventricle across different levels of biological organization, and to examine how such changes result in the modification of the functional properties of the heart. The structural remodelling response is thought to be responsible for changes in cardiac stiffness, the Ca2+ sensitivity of force generation and the rate of force generation by the heart. Such changes to both active and passive properties help to compensate for the loss of cardiac function caused by a decrease in physiological temperature. Hence, temperature-induced cardiac remodelling is common in fish that remain active following seasonal decreases in temperature. This Review is organized around the ventricular phases of the cardiac cycle – specifically diastolic filling, isovolumic pressure generation and ejection – so that the consequences of remodelling can be fully described. We also compare the thermal acclimation-associated modifications of the fish ventricle with those seen in the mammalian ventricle in response to cardiac pathologies and exercise. Finally, we consider how the plasticity of the fish heart may be relevant to survival in a climate change context, where seasonal temperature changes could become more extreme and variable.

DATA

Data di pubblicazione: 15/01/2017

AUTORI

KEEN ADAM N
KLAIMAN JORDAN M
SHIELS HOLLY A
GILLIS TODD E

ENTE DI AFFERENZA

CARDIOVASCULAR SCIENCE SCHOOL OF MEDICINE FACULTY OF BIOLOGY MEDICINE & HEALTH UNIV MANCHESTER MANCHESTER M13 9NT UK
DEPT REHABILITATION MEDICINE UNIV WASHINGTON SEATTLE WA 98109 USA
DEPT INTEGRATIVE BIOLOGY UNIV GUELPH GUELPH ONTARIO CANADA N1G 2W1

RIVISTA

The Journal of Experimental Biology, 220(2), 147-160

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