Pubblicazione scientifica

NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Abstract

Invasive mucinous lung adenocarcinoma ( IMA) is a rare subtype of lung adenocarcinoma with no effective treatment option in advanced disease. KRAS mutations occur in 28–87% of the cases. NRG1 fusions were recently discovered in KRAS‐negative IMA cases and otherwise negative for known driver oncogenes and could represent an attractive therapeutic target. Published data suggest that NRG1 fusions occur essentially in nonsmoking Asian women. From an IMA cohort of 25 French patients of known ethnicity, driver oncogenes EGFR, KRAS, BRAF, ERBB2 mutations, and ALK and ROS1 rearrangements presence were analyzed. In the IMA samples remaining negative for these driver oncogenes, an NRG1 rearrangement detection was performed by FISH. A driver oncogene was identified in 14/25 IMA, namely 12 KRAS mutations (48%), one ROS1 rearrangement (4%), and one ALK rearrangement (4%). The detection of NRG1 rearrangement by FISH was conducted in the 11 pan‐negative IMA. One sample was NRG1 FISH‐positive and 100% of the tumor nuclei analyzed were positive. This NRG1‐positive patient was a 61‐year‐old nonsmoking woman of Vietnamese ethnicity and was the sole patient of Asian ethnicity of the cohort. She died 6 months after the diagnosis with a pulmonary multifocal disease. NRG1 FISH detection should be considered in patients with IMA pan‐negative for known driver oncogenes. These results might suggest that NRG1 fusion is more frequent in IMA from Asian patient. Larger studies are needed.

DATA

Data di pubblicazione: 21/10/2016

AUTORI

DURUISSEAUX MICHAEL
MCLEER‐FLORIN ANNE
ANTOINE MARTINE
ALAVIZADEH SANAZ
POULOT VIRGINIE
LACAVE ROGER
RABBE NATHALIE
CADRANEL JACQUES
WISLEZ MARIE

ENTE DI AFFERENZA

SORBONNE UNIVERSITES UPMC UNIVERSITY PARIS 06 GRC N°04 THERANOSCAN F‐75252 PARIS FRANCE
PLATEFORME DE GENETIQUE MOLECULAIRE DES TUMEURS POLE DE BIOLOGIE ET PATHOLOGIE CHU GRENOBLE ET INSERM U 823‐INSTITUT A BONNIOT‐UNIVERSITE J FOURIER GRENOBLE FRANCE
AP‐HP HOPITAL TENON SERVICE D ANATOMIE PATHOLOGIQUE F‐75970 PARIS FRANCE
AP‐HP HOPITAL TENON PLATEFORME DE GENOMIQUE DES TUMEURS SOLIDES F‐75970 PARIS FRANCE
AP‐HP HOPITAL TENON SERVICE DE PNEUMOLOGIE F‐75970 PARIS FRANCE

RIVISTA

Cancer Medicine, 5(12), 3579-3585

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