Pubblicazione scientifica

Postprandial Levels of Branch Chained and Aromatic Amino Acids Associate with Fasting Glycaemia

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

High fasting plasma concentrations of isoleucine, phenylalanine, and tyrosine have been associated with increased risk of hyperglycaemia and incidence of type 2 diabetes. Whether these associations are diet or metabolism driven is unknown. We examined how the dietary protein source affects the postprandial circulating profile of these three diabetes associated amino acids (DMAAs) and tested whether the postprandial DMAA profiles are associated with fasting glycaemia. We used a crossover design with twenty-one healthy individuals and four different isocaloric test meals, containing proteins from different dietary sources (dairy, fish, meat, and plants). Analysis of the postprandial DMAAs concentrations was performed using targeted mass spectrometry. A DMAA score was defined as the sum of all the three amino acid concentrations. The postprandial area under the curve (AUC) of all the three amino acids and the DMAA score was significantly greater after intake of the meal with dairy protein compared to intake of the three other meals. The postprandial AUC for the DMAA score and all the three amino acids strongly associated with fasting glucose level and insulin resistance. This indicates the importance of the postprandial kinetics and metabolism of DMAAs in understanding the overall association between DMAAs and glycaemia.

DATA

Data di pubblicazione: 01/01/2016

AUTORI

OTTOSSON FILIP
ERICSON ULRIKA
ALMGREN PETER
NILSSON JEANETTE
MAGNUSSON MARTIN
FERNANDEZ CELINE
MELANDER OLLE

ENTE DI AFFERENZA

DEPT CLINICAL SCIENCES LUND UNIV JAN WALDENSTROMS GATA 35 21421 MALMO SWEDEN
DEPT CARDIOLOGY SKANE UNIV HOSPITAL ENTRANCE 35 20502 MALMO SWEDEN
DEPT INTERNAL MEDICINE SKANE UNIV HOSPITAL RUTH LUNDSKOGS GATA 3 20502 MALMO SWEDEN

RIVISTA

Journal of Amino Acids, 2016, 8576730

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