Pubblicazione scientifica

Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione

RIASSUNTO

Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 8-oxo-2′-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) levels, and we compared them among the cytogenetic subgroups established using fluorescence in situ hybridization (FISH). Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group. TP53 deletion patients exhibited a diminished DNA repair efficiency. Finally, cases with normal FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes.

DATA

Data di pubblicazione: 01/01/2014

AUTORI

COLLADO ROSA
IVARS DAVID
OLIVER ISABEL
TORMOS CARMEN
EGEA MERCEDES
MIGUEL AMPARO
SAEZ GUILLERMO T
CARBONELL FELIX

ENTE DI AFFERENZA

SERVICE OF HEMATOLOGY CDB UNIV GEN HOSPITAL OF VALENCIA
DEPT MEDICINE FACULTY OF MEDICINE UNIV VALENCIA
CIBEROBN BIOMEDICAL NETWORK RSCH CTR IN PHYSIOPATHOLOGY OF OBESITY & NUTRITION CHOUPANA SN 15706 SANTIAGO DE COMPOSTELA SPAIN
DEPT BIOCHEMISTRY & MOLECULAR BIOLOGY FACULTY OF MEDICINE UNIV VALENCIA
SERVICE OF CLINICAL ANALYSES CDB UNIV GEN HOSPITAL OF VALENCIA

RIVISTA

BioMed Research International, 2014, 686392

IMPACT FACTOR

2,140

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