DESCRIZIONE
A compound indicated by formula (1) or a pharmaceutically acceptable salt thereof, having an inhibitory activity in a fractalkine-CX3CR1 pathway. [R indicates a C1-6 alkyl group having 1-3 unsubstituted groups or 1-3 substituted groups selected from a group (A) of substituted groups, a C3-8 cycloalkyl group having 1-3 unsubstituted groups or 1-3 substituted groups selected from the group (A) of substituted groups, or a C3-8 cycloalkenyl group having 1-3 unsubstituted groups or 1-3 substituted groups selected from the group (A) of substituted groups; X indicates a C1-6 alkyl group; Y and Z are the same or different and indicate a halogen atom or a C1-6 alkyl group having 1-3 unsubstituted groups or 1-3 substituted groups selected from a group (B) of substituted groups; n indicates 0 or 1, the group (A) of substituted groups comprises halogen atoms; and the group (B) of substituted groups comprises halogen atoms.]