Pubblicazione scientifica

Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria

FILONE TECNOLOGICO	TEMA
economia circolare e sostenibilità

RIASSUNTO

Parasitic nematode infections cause debilitating diseases and impede economic productivity. Antinematode chemotherapies are fundamental to modern medicine and are also important for industries including agriculture, aquaculture and animal health. However, the lack of suitable treatments for some diseases and the rise of nematode resistance to many available therapies necessitates the discovery and development of new drugs. Here, marine epiphytic bacteria represent a promising repository of newly discovered antinematode compounds. Epiphytic bacteria are ubiquitous on marine surfaces where they are under constant pressure of grazing by bacterivorous predators (e.g., protozoans and nematodes). Studies have shown that these bacteria have developed defense strategies to prevent grazers by producing toxic bioactive compounds. Although several active metabolites against nematodes have been identified from marine bacteria, drug discovery from marine microorganisms remains underexplored. In this review, we aim to provide further insight into the need and potential for marine epiphytic bacteria to become a new source of antinematode drugs. We discuss current and emerging strategies, including culture-independent high throughput screening and the utilization of Caenorhabditis elegans as a model target organism, which will be required to advance antinematode drug discovery and development from marine microbial sources.

DATA

Data di pubblicazione: 11/12/2020

AUTORI

SALIKIN NOR HAWANI
NAPPI JADRANKA
MAJZOUB MARWAN E
EGAN SUHELEN

ENTE DI AFFERENZA

CTR MARINE SCIENCE & INNOV SCHOOL OF BIOLOGICAL EARTH & ENVIRONMENTAL SCIENCES UNSW SYDNEY NSW 2052 AUSTRALIA NORHAWANI0203 GMAIL COM NHS J NAPPI UNSW EDU AU JN M MAJZOUB UNSW EDU AU MEM
SCHOOL OF IND TECH UNIV SAINS MALAYSIA USM 11800 PENANG MALAYSIA

RIVISTA

Microorganisms, 8(12), 1963

IMPACT FACTOR

4,152

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