Pubblicazione scientifica

Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis

FILONE TECNOLOGICO	TEMA
trasformazione e commercializzazione	macchinari di ausilio alla lavorazione e trasformazione del pesce

RIASSUNTO

Objective

Mycobacterium marinum causes a rare cutaneous disease known as fish tank granuloma (FTG). The disease manifestations resemble those associated with Cutaneous Leishmaniasis (CL). The aim of this study was to determine whether FTG was the cause of cutaneous lesions in patients who were referred to the Parasitology laboratory of Imam Reza Hospital in Mashhad to be investigated for CL.

Materials/Methods

One hundered patients, clinically diagnosed with CL between April 2014 and March 2015, were included in this study. Ziehl-Neelsen staining was performed to identify acid-fast Mycobacterium in addition to bacterial cultures using Löwenstein-Jensen medium. Skin lesion samples were also collected and kept on DNA banking cards for PCR testing.

Results

Twenty-nine of the 100 individuals with skin lesions, and therefore suspected of suffering from CL, tested positive for Mycobacterium marinum by PCR. Of these, 21 (72.4%) were male and 8(27.6%) were female. In 97% of these cases the lesions were located on hands and fingers. These patients had a history of manipulating fish and had been in contact with aquarium water. A sporotrichoid appearance was observed in 58.6% of the patients with mycobacterial lesions; 67% of patients had multiple head appearance.

Conclusion

Patients suspected to have CL and who test negative for CL could be affected by FTG. Therefore, after obtaining an accurate case history, molecular diagnosis is recommended for cases that give a negative result by conventional methods.

DATA

Data di pubblicazione: 19/09/2019

AUTORI

FATA ABDOLMAJID
BOJDY AMIN
MALEKI MASOUD
HOSSEINI FARASH BIBI RAZIEH
GHAZVINI KIARASH
TAJZADEH PARASTOO
VAKILI VIDA
MOGHADDAS ELHAM
MASTROENI PIETRO
RAHMANI SHADI

ENTE DI AFFERENZA

CUTANEOUS LEISHMANIASIS RSCH CTR MASHHAD UNIV MEDICAL SCIENCES MASHHAD KHORASAN E RAZAVI IRAN
DEPT PARASITOLOGY & MYCOLOGY FACULTY OF MEDICINE MASHHAD UNIV MEDICAL SCIENCES MASHHAD KHORASAN E RAZAVI IRAN
DEPT INFECTIOUS DISEASES IMAM REZA HOSPITAL MASHHAD UNIV MEDICAL SCIENCES MASHHAD KHORASAN E RAZAVI IRAN
DEPT DERMATOLOGY IMAM REZA HOSPITAL MASHHAD UNIV MEDICAL SCIENCES MASHHAD KHORASAN E RAZAVI IRAN
DEPT MICROBIOLOGY QUEM HOSPITAL MASHHAD UNIV MEDICAL SCIENCES MASHHAD KHORASAN E RAZAVI IRAN
DEPT MEDICAL LAB SCIENCES FACULTY OF NURSING KASHMAR MASHHAD UNIV MEDICAL SCIENCES MASHHAD KHORASAN E RAZAVI IRAN
DEPT SOCIAL MEDICINE FACULTY OF MEDICINE MASHHAD UNIV MEDICAL SCIENCES MASHHAD KHORASAN E RAZAVI IRAN
DEPT VETERINARY MEDICINE UNIV CAMBRIDGE CAMBRIDGE UK
UNIV DEGLI STUDI DI PARMA ITALY

RIVISTA

PLoS ONE, 14(9), e0221367

IMPACT FACTOR

2,870

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