Pubblicazione scientifica

Algae Polyphenolic Compounds and Modern Antibacterial Strategies: Current Achievements and Immediate Prospects

FILONE TECNOLOGICO	TEMA
economia circolare e sostenibilità

RIASSUNTO

The increasing drug resistance of pathogenic microorganisms raises concern worldwide and necessitates the search for new natural compounds with antibacterial properties. Marine algae are considered a natural and attractive biotechnological source of novel antibiotics. The high antimicrobial activity of their polyphenolic compounds is a promising basis for designing innovative pharmaceuticals. They can become both a serious alternative to traditional antimicrobial agents and an effective supplement to antibiotic therapy. The present review summarizes the results of numerous studies on polyphenols from algae and the range of biological activities that determine their biomedical significance. The main focus is put on a group of the polyphenolic metabolites referred to as phlorotannins and, particularly, on their structural diversity and mechanisms of antimicrobial effects. Brown algae are an almost inexhaustible resource with a high biotechnological potential for obtaining these polyfunctional compounds. An opinion is expressed that the effectiveness of the antibacterial activity of phlorotannins depends on the methods of their extraction aimed at preserving the phenolic structure. The use of modern analytical tools opens up a broad range of opportunities for studying the metabolic pathways of phlorotannins and identifying their structural and functional relationships. The high antimicrobial activity of phlorotannins against both Gram-positive and Gram-negative bacteria provides a promising framework for creating novel drugs to be used in the treatment and prevention of infectious diseases.

DATA

Data di pubblicazione: 11/09/2020

AUTORI

BESEDNOVA NATALYA N
ANDRYUKOV BORIS G
ZAPOROZHETS TATYANA S
KRYZHANOVSKY SERGEY P
KUZNETSOVA TATYANA A
FEDYANINA LUDMILA N
MAKARENKOVA ILONA D
ZVYAGINTSEVA TATYANA N

ENTE DI AFFERENZA

SOMOV RSCH INST EPIDEMIOLOGY & MICROBIOLOGY 690087 VLADIVOSTOK RUSSIA ANDRUKOV BG MAIL RU BGA NIIEM VL MAIL RU TSZ TAKUZNETS MAIL RU TAK ILONA M MAIL RU IDM
SCHOOL OF BIOMEDICINE FAR EASTERN FEDERAL UNIV FEFU
MEDICAL ASSOC FAR EASTERN BRANCH RUSSIAN ACAD SCIENCES 690022 VLADIVOSTOK RUSSIA PRIEMMODVORAN MAIL RU
ELYAKOV PACIFIC INST BIOORGANIC CHEMISTRY FAR EASTERN BRANCH RUSSIAN ACAD SCIENCES 690022 VLADIVOSTOK RUSSIA ZVYAG PIBOC DVO RU

RIVISTA

Biomedicines, 8(9), 342

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