Pubblicazione scientifica

µ-Conotoxins Modulating Sodium Currents in Pain Perception and Transmission: A Therapeutic Potential

FILONE TECNOLOGICO	TEMA
economia circolare e sostenibilità	monitoraggio impatti climatici
trasformazione e commercializzazione	certificazione e marchi di qualità

RIASSUNTO

The Conus genus includes around 500 species of marine mollusks with a peculiar production of venomous peptides known as conotoxins (CTX). Each species is able to produce up to 200 different biological active peptides. Common structure of CTX is the low number of amino acids stabilized by disulfide bridges and post-translational modifications that give rise to different isoforms. µ and µO-CTX are two isoforms that specifically target voltage-gated sodium channels. These, by inducing the entrance of sodium ions in the cell, modulate the neuronal excitability by depolarizing plasma membrane and propagating the action potential. Hyperexcitability and mutations of sodium channels are responsible for perception and transmission of inflammatory and neuropathic pain states. In this review, we describe the current knowledge of µ-CTX interacting with the different sodium channels subtypes, the mechanism of action and their potential therapeutic use as analgesic compounds in the clinical management of pain conditions.

DATA

Data di pubblicazione: 22/09/2017

AUTORI

TOSTI ELISABETTA
BONI RAFFAELE
GALLO ALESSANDRA

ENTE DI AFFERENZA

DEPT BIOLOGY & EVOLUTION OF MARINE ORGANISMS STAZIONE ZOOLOGICA ANTON DOHRN VILLA COMUNALE 80121 NAPLES ITALY ELISABETTA TOSTI SZN IT
DEPT SCIENCES UNIV BASILICATA 75100 POTENZA ITALY RAFFAELE BONI UNIBAS IT

RIVISTA

Marine Drugs, 15(10), 295

IMPACT FACTOR

3,810

indietro