Pubblicazione scientifica

Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide.

DATA

Data di pubblicazione: 11/10/2018

AUTORI

DE LORGERIL JULIEN
LUCASSON AUDE
PETTON BRUNO
TOULZA EVE
MONTAGNANI CAROLINE
CLERISSI CAMILLE
VIDAL-DUPIOL JEREMIE
CHAPARRO CRISTIAN
GALINIER RICHARD
ESCOUBAS JEAN-MICHEL
HAFFNER PHILIPPE
DEGREMONT LIONEL
CHARRIERE GUILLAUME M
LAFONT MAXIME
DELORT ABIGAIL
VERGNES AGNES
CHIARELLO MARLENE
FAURY NICOLE
RUBIO TRISTAN
LEROY MARC A
PERIGNON ADELINE
REGLER DENIS
MORGA BENJAMIN
ALUNNO-BRUSCIA MARIANNE
BOUDRY PIERRE
LE ROUX FREDERIQUE
DESTOUMIEUX-GARZΟN DELPHINE
GUEGUEN YANNICK
MITTA GUILLAUME

RIVISTA

Nature Communications, 9, 4215

indietro