Pubblicazione scientifica

Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Methicillin-resistant Staphylococcus aureus (MRSA) pose a significant health threat as they tend to cause severe infections in vulnerable populations and are difficult to treat due to a limited range of effective antibiotics and also their ability to form biofilm. These organisms were once limited to hospital acquired infections but are now widely present in the community and even in animals. Furthermore, these organisms are constantly evolving to develop resistance to more antibiotics. This results in a need for new clinically useful antibiotics and one potential source are the Streptomyces which have already been the source of several anti-MRSA drugs including vancomycin. There remain large numbers of Streptomyces potentially undiscovered in underexplored regions such as mangrove, deserts, marine, and freshwater environments as well as endophytes. Organisms from these regions also face significant challenges to survival which often result in the production of novel bioactive compounds, several of which have already shown promise in drug development. We review the various mechanisms of antibiotic resistance in MRSA and all the known compounds isolated from Streptomyces with anti-MRSA activity with a focus on those from underexplored regions. The isolation of the full array of compounds Streptomyces are potentially capable of producing in the laboratory has proven a challenge, we also review techniques that have been used to overcome this obstacle including genetic cluster analysis. Additionally, we review the in vivo work done thus far with promising compounds of Streptomyces origin as well as the animal models that could be used for this work.

DATA

Data di pubblicazione: 24/09/2018

AUTORI

KEMUNG HEFA MANGZIRA
TAN LOH TENG-HERN
KHAN TAHIR MEHMOOD
CHAN KOK-GAN
PUSPARAJAH PRIYIA
GOH BEY-HING
LEE LEARN-HAN

ENTE DI AFFERENZA

NOVEL BACTERIA & DRUG DISCOVERY RSCH GROUP BIOMEDICINE RSCH ADVANCEMENT CTR SCHOOL OF PHARMACY MONASH UNIV MALAYSIA BANDAR SUNWAY MALAYSIA
BIOFUNCTIONAL MOLECULE EXPLORATORY RSCH GROUP BIOMEDICINE RSCH ADVANCEMENT CTR SCHOOL OF PHARMACY MONASH UNIV MALAYSIA BANDAR SUNWAY MALAYSIA
JEFFREY CHEAH SCHOOL OF MEDICINE & HEALTH SCIENCES MONASH UNIV MALAYSIA BANDAR SUNWAY MALAYSIA
INST PHARM SCIENCES IPS UNIV VETERINARY & ANIMAL SCIENCES UVAS LAHORE PAKISTAN
GENETICS & MOLECULAR BIOLOGY INST BIOLOGICAL SCIENCES FACULTY OF SCIENCE UNIV MALAYA KUALA LUMPUR MALAYSIA
INTL GENOME CTR JIANGSU UNIV ZHENJIANG CHINA
CTR HEALTH OUTCOMES RSCH & THERAPEUTIC SAFETY COHORTS SCHOOL OF PHARM SCIENCES UNIV PHAYAO MUEANG PHAYAO THAILAND

RIVISTA

Frontiers in Microbiology, 9, 2221

IMPACT FACTOR

4,190

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