Pubblicazione scientifica

Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer’s disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management.

DATA

Data di pubblicazione: 13/09/2018

AUTORI

PRASASTY VIVITRI
RADIFAR MUHAMMAD
ISTYASTONO ENADE

ENTE DI AFFERENZA

FACULTY OF BIOTECHNOLOGY ATMA JAYA CATHOLIC UNIV INDONESIA JAKARTA 12930 INDONESIA VIVITRI DEWI ATMAJAYA AC ID
DEPT MEDICAL LAB TECH ACAD HEALTH SCIENCES GUNA BANGSA CONDONGCATUR DEPOK SLEMAN YOGYAKARTA 55283 INDONESIA RADIFAR GUNABANGSA AC ID
FACULTY OF PHARMACY SANATA DHARMA UNIV PAINGAN MAGUWOHARJO DEPOK SLEMAN YOGYAKARTA 55282 INDONESIA

RIVISTA

Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 23(9), 2344

IMPACT FACTOR

3,010

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