Pubblicazione scientifica

Mitochondrial Glycolysis in a Major Lineage of Eukaryotes

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Abstract

The establishment of the mitochondrion is seen as a transformational step in the origin of eukaryotes. With the mitochondrion came bioenergetic freedom to explore novel evolutionary space leading to the eukaryotic radiation known today. The tight integration of the bacterial endosymbiont with its archaeal host was accompanied by a massive endosymbiotic gene transfer resulting in a small mitochondrial genome which is just a ghost of the original incoming bacterial genome. This endosymbiotic gene transfer resulted in the loss of many genes, both from the bacterial symbiont as well the archaeal host. Loss of genes encoding redundant functions resulted in a replacement of the bulk of the host’s metabolism for those originating from the endosymbiont. Glycolysis is one such metabolic pathway in which the original archaeal enzymes have been replaced by bacterial enzymes from the endosymbiont. Glycolysis is a major catabolic pathway that provides cellular energy from the breakdown of glucose. The glycolytic pathway of eukaryotes appears to be bacterial in origin, and in well-studied model eukaryotes it takes place in the cytosol. In contrast, here we demonstrate that the latter stages of glycolysis take place in the mitochondria of stramenopiles, a diverse and ecologically important lineage of eukaryotes. Although our work is based on a limited sample of stramenopiles, it leaves open the possibility that the mitochondrial targeting of glycolytic enzymes in stramenopiles might represent the ancestral state for eukaryotes.

DATA

Data di pubblicazione: 30/07/2018

AUTORI

RIO BARTULOS CAROLINA
ROGERS MATTHEW B
WILLIAMS TOM A
GENTEKAKI ELENI
BRINKMANN HENNER
CERFF RUDIGER
LIAUD MARIE-FRANCOISE
HEHL ADRIAN B
YARLETT NIGEL R
GRUBER ANSGAR
KROTH PETER G
VAN DER GIEZEN MARK

ENTE DI AFFERENZA

Leibniz-Institut DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH Braunschweig Germany
Institute of Parasitology Biology Centre Czech Academy of Sciences České Budějovice Czech Republic
INST FUR GENETIK TECH UNIV BRAUNSCHWEIG
FACHBEREICH BIOLOGIE UNIV KONSTANZ GERMANY
BIOSCIENCES UNIV EXETER UK
RANGOS RSCH CTR UNIV PITTSBURGH CHILDRENS HOSPITAL PITTSBURGH PA
SCHOOL OF BIOLOGICAL SCIENCES UNIV BRISTOL UK
DEPT BIOCHEMISTRY & MOLECULAR BIOLOGY DALHOUSIE UNIV HALIFAX CANADA
SCHOOL OF SCIENCE & HUMAN GUT MICROBIOME FOR HEALTH RSCH UNIT MAE FAH LUANG UNIV CHIANG RAI THAILAND
DEPT BIOCHIMIE UNIV MONTREAL CP 6128 MONTREAL QUEBEC CANADA
INST PARASITOLOGY UNIV ZURICH SWITZERLAND
DEPT CHEMISTRY & PHYSICAL SCIENCES PACE UNIV

RIVISTA

Genome Biology and Evolution, 10(9), 2310-2325

IMPACT FACTOR

3,726

indietro