Pubblicazione scientifica

Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish

FILONE TECNOLOGICO	TEMA
produzione e raccolta
trasformazione e commercializzazione

RIASSUNTO

Ectotherms choose the best thermal conditions to mount a successful immune response, a phenomenon known as behavioral fever. The cumulative evidence suggests that behavioral fever impacts positively upon lymphocyte proliferation, inflammatory cytokine expression, and other immune functions. In this study, we have explored how thermal choice during infection impacts upon underpinning molecular processes and how temperature increase is coupled to the immune response. Our results show that behavioral fever results in a widespread, plastic imprint on gene regulation, and lymphocyte proliferation. We further explored the possible contribution of histone modification and identified global associations between temperature and histone changes that suggest epigenetic remodeling as a result of behavioral fever. Together, these results highlight the critical importance of thermal choice in mobile ectotherms, particularly in response to an infection, and demonstrate the key role of epigenetic modification to orchestrate the thermocoupling of the immune response during behavioral fever.

DATA

Data di pubblicazione: 04/06/2018

AUTORI

BOLTANA SEBASTIAN
AGUILAR ANDREA
SANHUEZA NATALY
DONOSO ANDREA
MERCADO LUIS
IMARAI MONICA
MACKENZIE SIMON

ENTE DI AFFERENZA

INTERDISCIPLINARY CTR AQUACULTURE RSCH INCAR DEPT OCEANOGRAPHY BIOTECHNOLOGY CTR UNIV CONCEPCION CONCEPCION CHILE
GRUPO DE MARCADORES INMUNOLOGICOS FACULTAD DE CIENCIAS INST BIOLOGIA PONTIFICIA UNIV CATOLICA DE VALPARAISO VALPARAISO CHILE
LAB OF IMMUNOLOGY CTR AQUATIC BIOTECHNOLOGY DEPT BIOLOGY FACULTY OF CHEMISTRY & BIOLOGY UNIV SANTIAGO OF CHILE SANTIAGO CHILE
INST AQUACULTURE UNIV STIRLING STIRLING UK

RIVISTA

Frontiers in Immunology, 9, 1241

indietro