Pubblicazione scientifica

Mechanisms of Fish Macrophage Antimicrobial Immunity

FILONE TECNOLOGICO	TEMA
produzione e raccolta
trasformazione e commercializzazione

RIASSUNTO

Overcrowding conditions and temperatures shifts regularly manifest in large-scale infections of farmed fish, resulting in economic losses for the global aquaculture industries. Increased understanding of the functional mechanisms of fish antimicrobial host defenses is an important step forward in prevention of pathogen-induced morbidity and mortality in aquaculture setting. Like other vertebrates, macrophage-lineage cells are integral to fish immune responses and for this reason, much of the recent fish immunology research has focused on fish macrophage biology. These studies have revealed notable similarities as well as striking differences in the molecular strategies by which fish and higher vertebrates control their respective macrophage polarization and functionality. In this review, we address the current understanding of the biological mechanisms of teleost macrophage functional heterogeneity and immunity, focusing on the key cytokine regulators that control fish macrophage development and their antimicrobial armamentarium.

DATA

Data di pubblicazione: 28/05/2018

AUTORI

GRAYFER LEON
KERIMOGLU BARIS
YAPARLA AMULYA
HODGKINSON JORDAN W
XIE JIASONG
BELOSEVIC MIODRAG

ENTE DI AFFERENZA

DEPT BIOLOGICAL SCIENCES GEORGE WASHINGTON UNIV WASHINGTON DC US
DEPT BIOLOGICAL SCIENCES UNIV ALBERTA EDMONTON AB CANADA

RIVISTA

Frontiers in Immunology, 9, 1105

indietro