Pubblicazione scientifica

Physiological and Molecular Mechanisms of Methionine Restriction

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Methionine restriction (MR) has been studied extensively over the last 25 years for its role in altering metabolic hallmarks of disease. Animals subjected to MR, display changes in metabolic flexibility demonstrated by increases in energy expenditure, glucose tolerance, and lifespan. These changes have been well characterized in a number of model systems and significant progress has been made in understanding how hepatic fibroblast growth factor 21 links MR to several components of its metabolic phenotype. Despite these advances, a complete understanding of mechanisms engaged by dietary MR remains elusive. In this review, we offer a brief history of MR and its known mechanisms associated with stress, metabolism, and lifespan extension. We consider the role of epigenetics in the response of animals to MR and propose a novel epigenetic pathway involving the regulation of microRNAs during MR.

DATA

Data di pubblicazione: 04/05/2018

AUTORI

LATIMER MARY NESLUND
FREIJ KHALID WALID
CLEVELAND BETH M
BIGA PEGGY R

ENTE DI AFFERENZA

DEPT BIOLOGY UNIV ALABAMA AT BIRMINGHAM BIRMINGHAM AL US
NATL CTR COOL & COLD WATER AQUACULTURE AGRICULTURAL RSCH SRVC USDA KEARNEYSVILLE WV US

RIVISTA

Frontiers in Endocrinology, 9, 217

IMPACT FACTOR

3,630

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