Pubblicazione scientifica

Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Mangrove derived microorganisms constitute a rich bioresource for bioprospecting of bioactive natural products. This study explored the antioxidant potentials of Streptomyces bacteria derived from mangrove soil. Based on 16S rRNA phylogenetic analysis, strain MUM292 was identified as the genus Streptomyces. Strain MUM292 showed the highest 16S rRNA gene sequence similarity of 99.54% with S. griseoruber NBRC12873T. Furthermore, strain MUM292 was also characterized and showed phenotypic characteristics consistent with Streptomyces bacteria. Fermentation and extraction were performed to obtain the MUM292 extract containing the secondary metabolites of strain MUM292. The extract displayed promising antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging and also metal-chelating activities. The process of lipid peroxidation in lipid-rich product was also retarded by MUM292 extract and resulted in reduced MDA production. The potential bioactive constituents of MUM292 extract were investigated using GC-MS and preliminary detection showed the presence of pyrazine, pyrrole, cyclic dipeptides, and phenolic compound in MUM292 extract. This work demonstrates that Streptomyces MUM292 can be a potential antioxidant resource for food and pharmaceutical industries.

DATA

Data di pubblicazione: 01/04/2018

AUTORI

TAN LOH TENG-HERN
CHAN KOK-GAN
CHAN CHIM KEI
KHAN TAHIR MEHMOOD
LEE LEARN-HAN
GOH BEY-HING

ENTE DI AFFERENZA

NOVEL BACTERIA & DRUG DISCOVERY NBDD RSCH GROUP SCHOOL OF PHARMACY MONASH UNIV MALAYSIA 47500 BANDAR SUNWAY SELANGOR DARUL EHSAN MALAYSIA
BIOFUNCTIONAL MOLECULE EXPLORATORY RSCH GROUP BMEX SCHOOL OF PHARMACY MONASH UNIV MALAYSIA BANDAR SUNWAY SELANGOR DARUL EHSAN MALAYSIA
BIOMEDICAL RSCH LAB JEFFREY CHEAH SCHOOL OF MEDICINE & HEALTH SCIENCES MONASH UNIV MALAYSIA BANDAR SUNWAY SELANGOR DARUL EHSAN MALAYSIA
INTL GENOME CTR JIANGSU UNIV ZHENJIANG CHINA
GENETICS & MOLECULAR BIOLOGY INST BIOLOGICAL SCIENCES FACULTY OF SCIENCE UNIV MALAYA 50603 KUALA LUMPUR MALAYSIA
BIOMOLECULAR RSCH GROUP BIOCHEMISTRY PROGRAM INST BIOLOGICAL SCIENCES FACULTY OF SCIENCE UNIV MALAYA KUALA LUMPUR MALAYSIA
INST PHARM SCIENCES UNIV VETERINARY & ANIMAL SCIENCES LAHORE PAKISTAN
ASIAN CTR EVIDENCE SYNTHESIS IN POPULATION IMPLEMENTATION & CLINICAL OUTCOMES HEALTH & WELL BEING CLUSTER GLOBAL ASIA IN 21ST CENTURY PLATFORM MONASH UNIV MALAYSIA BANDAR SUNWAY SELANGOR DARUL EHSAN MALAYSIA
CTR HEALTH OUTCOMES RSCH & THERAPEUTIC SAFETY SCHOOL OF PHARM SCIENCES UNIV PHAYAO PHAYAO THAILAND

RIVISTA

BioMed Research International, 2018, 4823126

IMPACT FACTOR

2,140

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