Pubblicazione scientifica

The Antioxidative Function of Alpha-Ketoglutarate and Its Applications

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the oxidation of nutrients (i.e., amino acids, glucose, fatty acids) and then provides energy for cell processes. As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogen peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation. Recent studies also show that AKG has alleviative effect on oxidative stress as a source of energy and an antioxidant in mammalian cells. In this review, we highlight recent advances in the antioxidative function of AKG and its applications in animals and humans.

DATA

Data di pubblicazione: 21/03/2018

AUTORI

LIU SHAOJUAN
HE LIUQIN
YAO KANG

ENTE DI AFFERENZA

KEY LAB OF AGRO ECOLOGICAL PROCESSES IN SUBTROPICAL REGION INST SUBTROPICAL AGRICULTURE CHINESE ACAD SCIENCES NATL ENG LAB FOR POLLUTION CTRL & WASTE UTILIZATION IN LIVESTOCK & POULTRY PROD HUNAN PROVINCIAL ENG RSCH CTR HEALTHY LIVESTOCK & POULTRY PROD CHANGSHA HUNAN 410125 CHINA
UNIV CHINESE ACAD SCIENCES BEIJING 100049 CHINA

RIVISTA

BioMed Research International, 2018, 3408467

IMPACT FACTOR

2,140

indietro