Pubblicazione scientifica

Antiviral Defense and Innate Immune Memory in the Oyster

FILONE TECNOLOGICO	TEMA
economia circolare e sostenibilità
produzione e raccolta

RIASSUNTO

The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas combined with next-generation sequencing techniques has revealed that oysters have a complex antiviral response involving the activation of all major innate immune pathways. Experimental evidence indicates C. gigas utilizes an interferon-like response to limit OsHV-1 replication and spread. Oysters injected with a viral mimic (polyI:C) develop resistance to OsHV-1. Improved survival following polyI:C injection was found later in life (within-generational immune priming) and in the next generation (multi-generational immune priming). These studies indicate that the oyster’s antiviral defense system exhibits a form of innate immune-memory. An important priority is to identify the molecular mechanisms responsible for this phenomenon. This knowledge will motivate the development of practical and cost-effective treatments for improving oyster health in aquaculture.

DATA

Data di pubblicazione: 16/03/2018

AUTORI

GREEN TIMOTHY J
SPECK PETER

ENTE DI AFFERENZA

CTR SHELLFISH RSCH & DEPT FISHERIES & AQUACULTURE VANCOUVER ISLAND UNIV NANAIMO BC V9R 5S5 CANADA
DEPT BIOLOGICAL SCIENCES MACQUARIE UNIV SYDNEY NSW 2109 AUSTRALIA
COLLEGE OF SCIENCE & ENG FLINDERS UNIV GPO BOX 2100 ADELAIDE SA 5001 AUSTRALIA PETER SPECK FLINDERS EDU AU

RIVISTA

Viruses, 10(3), 133

IMPACT FACTOR

3,760

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