Pubblicazione scientifica

Nutrients and Oxidative Stress: Friend or Foe?

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

There are different types of nutritionally mediated oxidative stress sources that trigger inflammation. Much information indicates that high intakes of macronutrients can promote oxidative stress and subsequently contribute to inflammation via nuclear factor-kappa B- (NF-κB-) mediated cell signaling pathways. Dietary carbohydrates, animal-based proteins, and fats are important to highlight here because they may contribute to the long-term consequences of nutritionally mediated inflammation. Oxidative stress is a central player of metabolic ailments associated with high-carbohydrate and animal-based protein diets and excessive fat consumption. Obesity has become an epidemic and represents the major risk factor for several chronic diseases, including diabetes, cardiovascular disease (CVD), and cancer. However, the molecular mechanisms of nutritionally mediated oxidative stress are complex and poorly understood. Therefore, this review aimed to explore how dietary choices exacerbate or dampen the oxidative stress and inflammation. We also discussed the implications of oxidative stress in the adipocyte and glucose metabolism and obesity-associated noncommunicable diseases (NCDs). Taken together, a better understanding of the role of oxidative stress in obesity and the development of obesity-related NCDs would provide a useful approach. This is because oxidative stress can be mediated by both extrinsic and intrinsic factors, hence providing a plausible means for the prevention of metabolic disorders.

DATA

Data di pubblicazione: 31/01/2018

AUTORI

TAN BEE LING
NORHAIZAN MOHD ESA
LIEW WINNIE-PUI-PUI

ENTE DI AFFERENZA

DEPT NUTRITION & DIETETICS FACULTY OF MEDICINE & HEALTH SCIENCES UNIV PUTRA MALAYSIA 43400 SERDANG SELANGOR MALAYSIA
LAB OF MOLECULAR BIOMEDICINE INST BIOSCIENCE UNIV PUTRA MALAYSIA 43400 SERDANG SELANGOR MALAYSIA
RESEARCH CTR EXCELLENT NUTRITION & NON COMMUNICABLE DISEASES NNCD FACULTY OF MEDICINE & HEALTH SCIENCES UNIV PUTRA MALAYSIA 43400 SERDANG SELANGOR MALAYSIA

RIVISTA

Oxidative Medicine and Cellular Longevity, 2018, 9719584

IMPACT FACTOR

4,580

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