Acquacoltura Pubblicazione scientifica Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids FILONE TECNOLOGICO TEMA produzione e raccolta RIASSUNTO By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prepared compounds are highly active as antifoulants, no apparent synergy is observed by incorporating the oxime functionality into the dihydrostilbene scaffold. This observation is discussed in light of recently reported literature data on related marine natural antifoulants and antifouling hybrids as a potentially general strategy for generation of improved antifoulants.Electronic supplementary materialThe online version of this article (10.1007/s10126-018-9802-z) contains supplementary material, which is available to authorized users. DATA Data di pubblicazione: 01/01/2018 AUTORI MOODIE LINDON W K CERVIN GUNNAR TREPOS ROZENN LABRIERE CHRISTOPHE HELLIO CLAIRE PAVIA HENRIK SVENSON JOHAN RIVISTA Marine Biotechnology (New York, N.y.), 20(2), 257-267