Pubblicazione scientifica

Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

The long-lasting interest in bioactive molecules (namely toxins) produced by (microalga) dinoflagellates has risen in recent years. Exhibiting wide diversity and complexity, said compounds are well-recognized for their biological features, with great potential for use as pharmaceutical therapies and biological research probes. Unfortunately, provision of those compounds is still far from sufficient, especially in view of an increasing demand for preclinical testing. Despite the difficulties to establish dinoflagellate cultures and obtain reasonable productivities of such compounds, intensive research has permitted a number of advances in the field. This paper accordingly reviews the characteristics of some of the most important biotoxins (and other bioactive substances) produced by dinoflagellates. It also presents and discusses (to some length) the main advances pertaining to dinoflagellate production, from bench to large scale—with an emphasis on material published since the latest review available on the subject. Such advances encompass improvements in nutrient formulation and light supply as major operational conditions; they have permitted adaptation of classical designs, and aided the development of novel configurations for dinoflagellate growth—even though shearing-related issues remain a major challenge.

DATA

Data di pubblicazione: 20/12/2017

AUTORI

ASSUNCAO JOANA
GUEDES A CATARINA
MALCATA F XAVIER

ENTE DI AFFERENZA

LEPABE—Laboratory of Process Engineering Environment Biotechnology and Energy Rua Dr. Roberto Frias s/n P-4200-465 Porto Portugal; joanaleonardoassuncao@gmail.com
INTERDISCIPLINARY CTR MARINE & ENVIRONMENTAL RSCH CIIMAR UNIV PORTO TERMINAL DE CRUZEIROS DO PORTO DE LEIXOES
DEPT CHEM ENG UNIV PORTO

RIVISTA

Marine Drugs, 15(12), 393

IMPACT FACTOR

3,810

indietro