Pubblicazione scientifica

Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs.

DATA

Data di pubblicazione: 21/11/2017

AUTORI

AGRAWAL SHIVANKAR
ACHARYA DEBABRATA
ADHOLEYA ALOK
BARROW COLIN J
DESHMUKH SUNIL K

ENTE DI AFFERENZA

BIOTECHNOLOGY & MGMT OF BIORESOURCES DIVISION TERI DEAKIN NANO BIOTECHNOLOGY CTR ENERGY & RESOURCES INST NEW DELHI INDIA
CTR CHEMISTRY & BIOTECHNOLOGY SCHOOL OF LIFE & ENVIRONMENTAL SCIENCES DEAKIN UNIV WAURN PONDS VIC AUSTRALIA

RIVISTA

Frontiers in Pharmacology, 8, 828

IMPACT FACTOR

3,860

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