Pubblicazione scientifica

Gut Microbiota Analysis in Rats with Methamphetamine-Induced Conditioned Place Preference

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Methamphetamine abuse is a major public health crisis. Because accumulating evidence supports the hypothesis that the gut microbiota plays an important role in central nervous system (CNS) function, and research on the roles of the microbiome in CNS disorders holds conceivable promise for developing novel therapeutic avenues for treating CNS disorders, we sought to determine whether administration of methamphetamine leads to alterations in the intestinal microbiota. In this study, the gut microbiota profiles of rats with methamphetamine-induced conditioned place preference (CPP) were analyzed through 16S rRNA gene sequencing. The fecal microbial diversity was slightly higher in the METH CPP group. The propionate-producing genus Phascolarctobacterium was attenuated in the METH CPP group, and the family Ruminococcaceae was elevated in the METH CPP group. Short chain fatty acid analysis revealed that the concentrations of propionate were decreased in the fecal matter of METH-administered rats. These findings provide direct evidence that administration of METH causes gut dysbiosis, enable a better understanding of the function of gut microbiota in the process of drug abuse, and provide a new paradigm for addiction treatment.

DATA

Data di pubblicazione: 25/08/2017

AUTORI

NING TINGTING
GONG XIAOKANG
XIE LINGLING
MA BAOMIAO

ENTE DI AFFERENZA

COLLEGE OF LIFE SCIENCES JIANGHAN UNIV WUHAN CHINA
WUHAN INST BIOMEDICAL SCIENCE JIANGHAN UNIV WUHAN CHINA
KEY LAB OF COMBINATORIAL BIOSYNTHESIS & DRUG DISCOVERY WUHAN UNIV MINST EDUCATION WUHAN UNIV SCHOOL OF PHARM SCIENCES WUHAN CHINA

RIVISTA

Frontiers in Microbiology, 8, 1620

IMPACT FACTOR

4,190

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