Pubblicazione scientifica

Evaluation of Marine Microalga Diacronema vlkianum Biomass Fatty Acid Assimilation in Wistar Rats

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Diacronema vlkianum is a marine microalgae for which supposed health promoting effects have been claimed based on its phytochemical composition. The potential use of its biomass as health ingredient, including detox-shakes, and the lack of bioavailability studies were the main concerns. In order to evaluate the microalgae-biomass assimilation and its health-benefits, single-dose (CD1-mice) studies were followed by 66-days repeated-dose study in Wistar rats with the highest tested single-dose of microalgae equivalent to 101 mg/kg eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA). Microalgae-supplementation modulated EPA and docosapentaenoic acid enrichment at arachidonic acid content expenditure in erythrocytes and liver, while increasing EPA content of heart and adipose tissues of rats. Those fatty acid (FA) changes confirmed the D. vlkianum-biomass FA assimilation. The principal component analyses discriminated brain from other tissues, which formed two other groups (erythrocytes, liver, and heart separated from kidney and adipose tissues), pointing to a distinct signature of FA deposition for the brain and for the other organs. The improved serum lipid profile, omega-3 index and erythrocyte plasticity support the cardiovascular benefits of D. vlkianum. These results bolster the potential of D. vlkianum-biomass to become a “heart-healthy” food supplement providing a safe and renewable source of bioavailable omega-3 FA.

DATA

Data di pubblicazione: 01/07/2017

AUTORI

DE MELLO-SAMPAYO CRISTINA
PATERNA ANGELA
POLIZZI AMBRA
DUARTE DIANA
BATISTA IRINEU
PINTO RUI
GONCALVES PATRICIA
RAYMUNDO ANABELA
BATISTA ANA P
GOUVEIA LUISA
SILVA-LIMA BEATRIZ
BANDARRA NARCISA M

ENTE DI AFFERENZA

DEPT PHARMACOLOGICAL SCIENCES IMED ULISBOA FACULDADE DE FARMACIA UNIV LISBOA LISBON 1649 003 PORTUGAL CSAMPAYO GMAIL COM CDM S APATERNA GMAIL COM AP AMBRA POLIZZI GMAIL COM AP RAPINTO FF UL PT RP BEATRIZLIMA NETCABO PT BS L
AQUACULTURE & UPGRADING PORTUGUESE INST SEA & ATMOSPHERE IPMA IP
MODELLING & MARINE RESOURCES PORTUGUESE INST SEA & ATMOSPHERE IPMA IP
LEAF LINKING LANDSCAPE ENVIRONMENT AGRICULTURE & FOOD RSCH CTR INST SUPERIOR DE AGRONOMIA UNIV LISBOA TAPADA DA AJUDA 1349 017 LISBON PORTUGAL ANABRAYMUNDO ISA ULISBOA PT AR APBATISTA GMAIL COM APB
LNEG BIOENERGY UNIT ESTRADA DO PACO DO LUMIAR 22 1649 038 LISBON PORTUGAL LUISA GOUVEIA LNEG PT
INTERDISCIPLINARY CTR MARINE & ENVIRONMENTAL RSCH CIIMAR CIMAR UNIV PORTO

RIVISTA

Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 22(7), 1097

IMPACT FACTOR

3,010

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